Rosenberg was involved in advanced research at the Black Mesa Research Facility and was involved in the design of the Anti-Mass Spectrometer as well as being one of the first scientists involved in teleportation research.
Dr. Dwight Rosenberg arrived at the funeral of his old friend Walter Bennett, alongside Simmons. He reunited with Barney Calhoun. At the request of Nathan Johnson, Rosenberg agreed to have a look at Walter's project at his lab in City 17. He informs Nathan that some data has been stolen, which Nathan deduces as the work of the Clandestine Company.
- Rosenberg originated in the Half-Life expansion packs Half-Life: Blue Shift and Half-Life: Decay.